Catharine, born in Bologna, was related to the nobility in Ferrara and was educated at court there. She received a liberal education at the court and developed some interest and talent in painting. In later years as a Poor Clare, Catharine sometimes did manuscript illumination and also painted miniatures.

At the age of 17, she joined a group of religious women in Ferrara. Four years later the whole group joined the Poor Clares in that city. Jobs as convent baker and portress preceded her selection as novice mistress.

In 1456, she and 15 other sisters were sent to establish a Poor Clare monastery in Florence. As abbess Catharine worked to preserve the peace of the new community. Her reputation for holiness drew many young women to the Poor Clare life. She was canonized in 1712.